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优保津(Neupogen)系美国安进公司应用重组DNA技术生产的甲硫氨酸人粒细胞集落刺激因子(Granulocyte colony-stimulating factor,G-CSF)。体内外实验与观察均已证实,G-CSF可以促进造血辅助细胞增殖分化,明显增加外周血中性粒细胞数,并有增强粒细胞的功能,如对成熟的中性粒细胞可增强其吞噬活性和抗体依赖性细胞介导的细胞毒作用。1 适应征 ①骨髓移植(BMT)患者无白细胞期:有明显促进白细胞尤其是粒细胞恢复的作用,可降低BMT早期的感染发病率,提高BMT的安全性。
Neupogen is a methionine-derived human granulocyte colony-stimulating factor (G-CSF) produced by Amgen Corporation using recombinant DNA technology. In vitro and in vivo experiments and observations have confirmed that G-CSF can promote the proliferation and differentiation of hematopoietic cells, significantly increase the number of peripheral blood neutrophils, and enhance the function of granulocytes, such as the mature neutrophils can enhance their phagocytosis Activity and antibody-dependent cell-mediated cytotoxicity. 1 indications ① bone marrow transplantation (BMT) patients without leukocyte: significantly promote the recovery of leukocytes, especially granulocytes, can reduce the incidence of early BMT infection and improve the safety of BMT.