Walshe 等曾报告 Wilson 病患者对青霉胺疗法不依从的危险。最近 Scheinberg 等报告了停用青霉胺的临床后果以及应用三乙撑四胺(trientine)来预防青霉胺疗法中断所产生的影响。这两篇文章都没有提到口服锌是否可作为一种有效的替换疗法。许多研究已表明锌治疗 Wilson 病是有效的。作者对成年患者的研究显示口服锌可以在青霉胺治疗开始后作为维持治疗。其他研究者亦曾报告长期使用锌治疗Wilson 病取得有希望的结果。此外,作者用锌治疗 Walshe et al. Reported on the risk of non-adherence to penicillamine in patients with Wilson’s disease. Scheinberg et al. Recently reported on the clinical consequences of discontinuation of penicillamine and the use of trientine to prevent the effects of penicillamine therapy discontinuation. Neither article mentions whether oral zinc can be an effective replacement therapy. Many studies have shown that zinc is effective in treating Wilson’s disease. Authors’ studies of adult patients have shown that oral zinc can be used as maintenance treatment after penicillamine therapy begins. Other investigators have also reported promising results in the long-term treatment of Wilson’s disease with zinc. In addition, the authors treated with zinc