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本文研究了左旋18-甲基炔诺酮避孕药环体外释放量的一种测定方法——升降法。在37℃恒温条件下,药环浸在介质中以恒定的频率和振幅上下振动。介质的体积和搅拌速度都符合“漏槽”状态。用紫外分光光度法测定18-甲基炔诺酮的释放量。测定结果表明,经12～14天的快速释放后可维持稳态释放,释放的重现性较好。确认这一方法可用于18-甲基炔诺酮避孕药环体外释放量的测定。
In this paper, we investigated the release of 18-norgestrel from the loop of the L-18-norgestrel as a method for determination of the release volume outside the loop. Under a constant temperature of 37 ° C, the drug ring is immersed in a medium and vibrated up and down at a constant frequency and amplitude. Medium size and stirring speed are in line with the “drain” state. Determination of 18-norgestrel release by UV spectrophotometry. The results show that after 12 to 14 days of rapid release can maintain steady-state release, the release of good reproducibility. Confirmed that this method can be used for 18-norgestrel contraceptive ring volume release determination.