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4组大鼠分别喂以玉米面为主组成单一的偏食或常规食。两个月后间隔16h注射速尿两次。偏食组有明显反应,再注射NaNO_2或异丙基肾上腺素(ISP),发生严重心肌坏死,坏死程度显著重于常规食组(P<0.01)。这一动物模型有利于说明膳食因素对克山病心肌坏死的影响及进一步研究克山病心肌坏死的发生机理。
The four groups of rats were fed with cornmeal as the main composition of a single partial or normal food. Two months later, 16 hours after injection of furosemide twice. In the partial esophagus group, there was a significant response. After injection of NaNO 2 or isoproterenol (ISP), severe myocardial necrosis occurred and the degree of necrosis was significantly heavier than that of the routine food group (P<0.01). This animal model is helpful to explain the influence of dietary factors on myocardial necrosis of Keshan disease and further study the mechanism of myocardial necrosis of Keshan disease.