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目的:通过百合知母汤对哮喘大鼠的干预,探讨该治疗方法的作用机理。方法:将大鼠随机分成正常组、哮喘模型组、中药大、中、小剂量组、地米组、中西药联用组,除正常组外经卵蛋白免疫建立模型,ELISA法检测各组血清和BALF中SP-A的含量;计算肺脏、胸腺和脾脏的脏器系数。结果:与正常组相比,模型组及小剂量组血清、BALF中SP-A明显降低(P<0.05);与模型组比较,中药各剂量组、地米组及中西药联用组血清和BALF中SP-A有统计学意义(P<0.05);中药各剂量组间比较,中剂量组血清和BALF中SP-A均高于小剂量组,差异有统计学意(P<0.05);模型组肺脏器系数明显高于正常对照组(P<0.05)。结论:百合知母汤可显著升高血清和BALF中SP-A含量,对肺组织有很大影响。
Objective: To investigate the mechanism of action of Lily Zhimu Decoction on asthma rats. Methods: The rats were randomly divided into normal group, asthma model group, traditional Chinese medicine large, medium and small dose group, the group of rice, combination of Chinese and Western medicine, in addition to the normal group by the ovalbumin immunization model, ELISA assay serum And BALF SP-A content; calculate lung, thymus and spleen organ coefficients. Results: Compared with the normal group, SP-A in the serum and BALF in the model group and the low-dose group was significantly lower than that in the normal group (P <0.05). Compared with the model group, SP-A in BALF was significantly higher than that in the low-dose group (P <0.05). There was a statistically significant difference (P <0.05) between SP-A and BALF in the middle-dose group. The lung coefficient of the model group was significantly higher than that of the normal control group (P <0.05). Conclusion: Lily Zhimu Tang can significantly increase serum and BALF SP-A content, have a great impact on lung tissue.