C-C亚族趋化因子主要趋化和激活单核细胞及某些T细胞亚群,对嗜酸性粒细胞、嗜碱性粒细胞以及自然杀伤细胞亦有不同作用,进而参与炎症过程。其中单核细胞趋化蛋白(MCP)-1和正常T细胞活化后表达和分泌的调节蛋白(RANTES)是巨噬细胞的特异性趋化因子,高糖、糖化血红蛋白及肾素-血管紧张素系统可促进其高表达,从而使巨噬细胞在肾脏聚集和活化,在糖尿病肾病肾小球硬化以及肾小管间质纤维化的发生、发展中发挥着重要作用。其中,核因子-κB可能参与了高糖对MCP-1的上调作用。 Chemokines C-C chemokines mainly chemotactic and activate monocytes and some T cell subsets, also have different effects on eosinophils, basophils and natural killer cells, and then participate in the inflammatory process. RANTES, which is expressed and secreted after activation of monocyte chemotactic protein (MCP) -1 and normal T cells, is a macrophage-specific chemokine, high glucose, glycated hemoglobin and renin-angiotensin System can promote its high expression, so that macrophages in the kidney aggregation and activation, in diabetic nephropathy glomerulosclerosis and tubulointerstitial fibrosis occurrence and development play an important role. Among them, NF-κB may be involved in the upregulation of MCP-1 by high glucose.