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为了不断提高临床用药的合理性及疗效水平,随机检出门诊部分处方7250张,对其用药合理性进行评估,发现不合理用药的处方179张,占2.5％,具体分析如下。一、降低药物疗效的配伍属此类处方有144张,占80.4％。主要有: 1.青霉素(肌注)与麦迪霉素或红霉素(口服)伍用,此类处方有17张,占9.5％(17/179)。麦迪霉素、红霉素为速效抑菌剂,可抑制细菌蛋白质合成,使其体积不增大,也不产生细胞壁合成,而青霉素在于干扰细菌细胞壁合成,两者合用则使青霉素致细胞壁作用无从发挥。青霉素类杀菌剂不应与大环内脂类抑菌剂(包括红霉素、白霉素、乙酰螺旋霉素、麦迪霉素)合用。
In order to continuously improve the rationality of clinical medication and the level of efficacy, 7250 prescriptions of outpatients were randomly selected to assess the rationality of their medication and 179 prescriptions were found to be irrational, accounting for 2.5%. The specific analysis is as follows. First, to reduce the efficacy of drug compatibility There are 144 such prescriptions, accounting for 80.4%. Mainly: 1. Penicillin (intramuscular injection) and midecamycin or erythromycin (oral) Wu Wu, such prescription has 17, accounting for 9.5% (17/179). Midecamycin, erythromycin is a quick bacteriostatic agent that can inhibit bacterial protein synthesis, so that its volume does not increase, does not produce cell wall synthesis, and penicillin is the interference of bacterial cell wall synthesis, the combination of the two penicillin caused cell wall effect Play Penicillin fungicides should not be combined with macrolide antibiotics (including erythromycin, leucine, acetylspiramycin, midecamycin).