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尼莫地平为一种钙离子拮抗剂,对急性脑梗塞有治疗作用。但目前还没有资料证实尼莫地平有抗血小板的作用。本试验观察了尼莫地平在一组正常受试者中对血小板功能的影响。12名健康受试者(男6名、女6名),平均年龄32.9±5.6(22～44)岁,在试验开始前2周及试验的9天中不能服用任何药物,于服药前及末次给药后分别测定出血时间,同时作血生化、全血细胞计数、血小板计数、妊娠试验,以排除其他疾病或妊娠。试验分两个阶段:第一阶段受试者每6h 服尼莫
Nimodipine is a calcium antagonist that has a therapeutic effect on acute cerebral infarction. However, there is no data to confirm the anti-platelet effect of nimodipine. This experiment examined the effect of nimodipine on platelet function in a panel of normal subjects. Twelve healthy subjects (6 males and 6 females) with an average age of 32.9 ± 5.6 (22-44 years), were unable to take any medication for 2 weeks prior to the start of the trial and for 9 days of the trial, After administration, bleeding time was measured, blood biochemistry, whole blood count, platelet count and pregnancy test were performed at the same time to rule out other diseases or pregnancy. The experiment was divided into two phases: In the first phase, the subjects took nimol every 6 hours