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目的:观察氨氯地平加氢氯噻嗪治疗盐敏感性高血压临床疗效及不良反应。方法:选择盐敏感性轻、中度高血压44例,随机分为观察组和对照组各22例。观察组采用口服氨氯地平加氢氯噻嗪治疗,氨氯地平每次2.5mg,每天1次,氢氯噻嗪每次10mg,每天1次;服药2周后,降压效果不理想者将氨氯地平增加至5mg。对照组采用口服贝那普利治疗,每次10mg,每天1次。服药2周后,降压效果不理想者增加至15mg。两组均治疗12周,比较两组治疗后血压变化和不良反应。结果:治疗后,观察组与对照组收缩压(SBP)和舒张压(DBP)分别为(121.55±25.55)(79.59±5.23)和(138.95±11.97)(86.23±7.14)mmHg,两组比较,差异非常显著(P<0.0)。两组未发生不良反应。结论:氨氯地平加氢氯噻嗪治疗盐敏感性高血压优于贝那普利,且安全。
Objective: To observe the clinical efficacy and adverse reactions of amlodipine plus hydrochlorothiazide in the treatment of salt-sensitive hypertension. Methods: Forty-four patients with salt-sensitive light and moderate hypertension were randomly divided into observation group and control group with 22 cases each. The observation group was treated with oral amlodipine plus hydrochlorothiazide, with amlodipine 2.5mg once daily and hydrochlorothiazide 10mg once daily. Amlodipine was increased to 5mg after 2 weeks of taking the antihypertensive effect . The control group was treated with oral benazepril 10 mg once daily. After 2 weeks of medication, antihypertensive effect is not ideal to 15mg. The two groups were treated for 12 weeks, comparing the two groups of blood pressure changes and adverse reactions. Results After treatment, the SBP and DBP in the observation group and the control group were (121.55 ± 25.55) and (79.59 ± 5.23) and (138.95 ± 11.97) and (86.23 ± 7.14) mmHg, respectively The difference was significant (P <0.0). No adverse reactions occurred in both groups. CONCLUSION: Amlodipine plus hydrochlorothiazide is superior to benazepril in the treatment of salt-sensitive hypertension and is safe.