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1.经实验证明:自陕西省榆林地区所产披针叶黄华所提取的总碱对动物有明显的横纹肌松弛作用。家兔垂头量为603.00±72.63毫克/公斤,呼吸麻痹量为861.60毫克/公斤;狗的垂头量为416.40±21.20毫克/公斤。作用部位在神经、肌肉接头处,与右旋筒箭毒一样,属于非去极化型; 2.总碱有降压、减慢心率、释放组织胺作用对心脏有一定的抑制作用; 3.总碱过量有抑制呼吸的作用。持续有效的人工呼吸是解救呼吸抑制的基本方法,注射甲基硫酸新斯的明是解毒的有效措施; 4.小白鼠一次腹腔注射总碱的LD_(50)=1938毫克/公斤; 5.本药毒性较大。
1. Experimental results show that: the total alkaloids extracted from the Phyllostachys pubescens grown in Yulin, Shaanxi Province have obvious striated relaxation effect on animals. The dropping amount of rabbit was 603.00 ± 72.63 mg / kg, respiratory paralysis was 861.60 mg / kg, and dog’s dropping amount was 416.40 ± 21.20 mg / kg. The role of the site in the nerve, muscle joints, and right-bellied poisonous, belong to non-depolarization type; 2. Total alkaloids have antihypertensive, slow heart rate, release of histamine effect on the heart have a certain degree of inhibition; Total alkaloids inhibit the role of breathing. Sustained and effective artificial respiration is the basic method to rescue respiratory depression, injection of neostigmine methylsulfate is an effective detoxification measures; 4. a mouse intraperitoneal injection of LD_ (50) = 1938 mg / kg; Drug toxicity.