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黄体功能不全(LPD)系指子宫内膜发育不良,影响孕卵的种植,导致不孕和反复流产。LPD的发生原因可能与卵泡发育不全有关,但 Keller 氏报导在少数病人中子宫内膜孕酮(P)受体不足。正常卵泡发育决定于促性腺激素和雌二醇(E_2)的连续刺激,并反映在血清和卵泡液中二种激素水平的不断增加。LPD 的诊断一方面依赖于活检所取得之内膜与实际周期的日数相差多于2~+日,此外也表现为黄体期的孕激素水平过低,但对血清孕激素和子宫内膜发育间的关系却没有进行必要的探讨。甾体激素对靶器官-子宫内膜-的作用是通过它与胞质内的受体相结合,然后移位及胞核,通过与染色质
Luteal insufficiency (LPD) refers to endometrial dysplasia, affecting the growth of pregnant eggs, leading to infertility and recurrent miscarriage. The cause of LPD may be related to follicular hypoplasia, but Keller reports the lack of endometrial progesterone (P) receptors in a minority of patients. Normal follicular development is continually stimulated by gonadotrophin and estradiol (E_2) and reflects the increasing levels of both hormones in serum and follicular fluid. On the one hand, the diagnosis of LPD depends on the biopsy obtained intima and the actual number of days more than 2 ~ + days, in addition also showed the progesterone level of the luteal phase is too low, but the serum progesterone and endometrial development The relationship has not been necessary to explore. The effect of steroid hormones on the target organ - the endometrium - is through its binding to receptors in the cytoplasm, and then to the nucleus, through the interaction with chromatin