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Static magnetic field(SMF) has been known to affect cell proliferation in a cell-type-dependent manner,while the mechanism still remains unclear. We found that 1T moderate intensity SMF inhibits cell proliferation of nasopharyngeal carcinoma CNE-2Z cells and the Akt/m TOR signaling pathway, which is upregulated in many cancers. m TOR inhibitors are potential chemodrugs, but their clinical effects are limited by the feedback reactivation of other signaling components such as EGFR and Akt.We showed that 1 T SMF increases the antitumor efficacy of m TOR inhibitor Torin 2. In addition, 1 T SMF increases the inhibition efficiency on m TOR substrates phosphorylation and represses the m TOR inhibitor-induced feedback reactivation of EGFR and Akt. Our study not only demonstrates that m TOR/Akt pathway is one of the molecular targets of SMFs in cells, but also reveals the clinical potentials of combinations of m TOR inhibitors and SMFs in cancer treatment.
We found that 1T moderate intensity SMF inhibits cell proliferation of nasopharyngeal carcinoma CNE-2Z cells and the Akt / m TOR signaling pathway, which is upregulated in many cancers. m TOR inhibitors are potential chemodrugs, but their clinical effects are limited by the feedback reactivation of other signaling components such as EGFR and Akt. We showed that 1 T SMF increases the antitumor efficacy of m TOR inhibitor Torin 2. In addition, 1 T SMF increases the inhibition efficiency on m TOR substrates phosphorylation and repress the m TOR inhibitor-induced feedback reactivation of EGFR and Akt. Our study not only that m TOR / Akt pathway is one of the molecular targets of SMFs in cells, but also reveals the clinical potentials of combinations of m TOR inhibitors and SMFs in cancer treatment.