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目的观察鱼精蛋白1(PRM1)在结肠腺癌患者血清中的含量及其在癌组织中的表达情况,探讨其临床意义。方法 ELISA试验检测我院60例结肠癌患者和60例健康志愿者血清PRM1水平,免疫组化实验检测PRM1在结肠癌组织中的阳性表达率。结果结肠癌患者血清PRM1水平显著高于健康志愿者(P<0.01)。结肠癌患者癌组织内PRM1阳性率达86.7%(52/60)。结论 RRM1可能作为结肠癌的一个敏感指标在分子诊断或免疫治疗中发挥重要作用。
Objective To investigate the content of protamine 1 (PRM1) in the serum of patients with colon adenocarcinoma and its expression in cancer tissues and to explore its clinical significance. Methods Serum PRM1 level was detected by ELISA in 60 patients with colon cancer and 60 healthy volunteers in our hospital. The positive rate of PRM1 expression in colon cancer tissues was detected by immunohistochemistry. Results Serum PRM1 levels in patients with colon cancer were significantly higher than those in healthy volunteers (P <0.01). The positive rate of PRM1 in colon cancer patients was 86.7% (52/60). Conclusion RRM1 may play an important role in molecular diagnosis or immunotherapy as a sensitive indicator of colon cancer.