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目的 探讨ＣＤ４４ Ｖ６ 在乳腺癌中的表达及其意义。方法 应用免疫组织化学ＳＰ 法检测５４ 例乳腺癌组织中ＣＤ４４ Ｖ６ 基因蛋白表达变化。结果 乳腺癌ＣＤ４４ Ｖ６ 阳性率为５９ ．３ ％ （３２／５４） ，良性肿瘤的阳性率为２７ ．３ ％ （３／１１） ，Ｐ＜ ０ ．０５ 。有淋巴结转移者ＣＤ４４ Ｖ６ 高表达者的阳性率为６９ ．２ ％ （１８／２６） ，低表达者的阳性率为７ ．７ ％ （２／２６） 。在无淋巴结转移者中，浸润性癌高表达阳性率为５４ ．５ ％ （１２／２２） ，低表达阳性率为１３ ．６ ％ （３／２２） ；非浸润性癌高表达阳性率为３３ ．３ ％ （２／６） ，低表达阳性率为１６ ．７ ％ （１／６） ，Ｐ＜ ０ ．０５ 。结论 ＣＤ４４ Ｖ６ 在乳腺癌中的异常表达可能是乳腺癌发生、发展、转移的１ 个重要分子学改变。
Objective To investigate the expression of CD44 V6 in breast cancer and its significance. Methods Immunohistochemical SP method was used to detect the protein expression of CD44 V6 in 54 cases of breast cancer. Results The positive rate of CD44 V6 in breast cancer was 59. 3% (32/54), the positive rate of benign tumor was 27. 3% (3/11), P <0. 05. The positive rate of CD44 V6 with lymph node metastasis was 69. 2% (18/26), the positive rate of low expression was 7. 7% (2/26). Among those without lymph node metastasis, the positive rate of invasive carcinoma was 54. 5% (12/22), the low positive rate was 13. 6% (3/22). The positive rate of non-invasive carcinoma was 33. 3% (2/6), low expression positive rate of 16. 7% (1/6), P <0. 05. Conclusion The abnormal expression of CD44 V6 in breast cancer may be an important molecular change in the occurrence, development and metastasis of breast cancer.