山莨菪碱(654-Ⅱ)能否减少缺氧时心肌细胞胞浆内游离钙浓度([Ca~(2+)]i)尚未见报导。本文对比观察了缺氧时654-Ⅱ和异搏定对分离的成年大鼠心肌细胞杆形率和[Ca~(2+)]i的影响。胞浆内[Ca~(2+)]i测定采用荧光法(Futa-2为荧光指示剂)。实验分为三组:654-Ⅱ组(150μm/L)、异搏定组(100μm/L)和对照组。各组均 Anisodamine (654-Ⅱ) can reduce the intracellular free calcium concentration of cardiomyocytes during hypoxia ([Ca ~ (2 +)] i) has not been reported. In this paper, we compared the effects of 654-Ⅱ and verapamil on the cardiomyocyte rod shape and [Ca ~ (2 +)] i in adult rats exposed to hypoxia. The cytoplasm [Ca ~ (2 +)] i was measured by fluorescence method (Futa-2 fluorescence indicator). The experiment was divided into three groups: 654-Ⅱ group (150μm / L), verapamil group (100μm / L) and control group. Each group are