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血管阻力增高是大多数慢性高血压患者动脉压升高的原因.降压治疗的理想血流动力学作用是用直接作用于血管平滑肌的药物扩张收缩的小动脉,不影响心脏和减少静脉回流.肼苯哒嗪、氯苯甲噻二嗪、敏乐定和胍乙啶都是直接作用于血管平滑肌,从而引起血管扩张的药物.氯苯甲噻二嗪,肼苯哒嗪松弛血管的作用主要取决于细胞外液钙离子的浓度,当组织浸浴液中有额外的钙离子时,此作用就减弱.钙拮抗剂是一类独特的降压药物,能干扰钙离子从肌浆网进入细胞浆,致使心肌收
Increased vascular resistance is responsible for the increased arterial pressure in most patients with chronic hypertension.The ideal hemodynamic effect of antihypertensive therapy is the expansion of contracting arterioles with drugs acting directly on vascular smooth muscles without affecting the heart and reducing venous return. Hydralazine, Clofazidimethazide, Minotidine, and Guanethidine are all drugs which act directly on vascular smooth muscle and cause vasodilatation.Chlorbenzothiadiazide and hydralazine relax the blood vessels mainly Depending on the extracellular calcium concentration, this effect diminishes when extra calcium ions are present in the tissue immersion bath.Calcium antagonists are a unique class of antihypertensive drugs that interfere with the entry of calcium ions from the sarcoplasmic reticulum into cells Pulp, resulting in myocardial contraction