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目的了解围绝经期女性雌激素与非高密度脂蛋白胆固醇(non-HDL-C)的关系。方法选取212例女性,其中围绝经期组112例,正常对照组100例,所有受试者分别检测总胆固醇(TC)、甘油三酯(TG)、低密度度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清促卵泡刺激激素(FSH)、血清促黄体生成素(LH)、雌二醇(E2)及血压测量,并计算体重指数、non-HDL-C。结果围绝经期组的TC、TG、LDL-C、non-HDL-C、FSH、LH水平明显高于对照组,而HDL-C、E2低于对照组,围绝经期组的E2与TC、TG、LDL-C、non-HDL-C、FSH、LH呈负相关,与HDLC呈正相关;HDL-C随E2水平增高而增高,TC、TG、LDL-C、non-HDL-C随着E2水平下降而增高;non-HDL-C与TG、LDL-C均呈线性关系。结论围绝经期女性E2水平低于正常女性,其变化与non-HDL-C有一定相关性,nonHDL-C可以作为调脂管理新目标。
Objective To investigate the relationship between estrogen and non-HDL-C in perimenopausal women. Methods A total of 212 women were enrolled in this study. Among them, there were 112 cases of perimenopausal group and 100 cases of normal control group. All subjects were tested for total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) , HDL-C, FSH, LH, E2 and blood pressure were calculated, body mass index, non-HDL-C . Results Peri-menopausal group TC, TG, LDL-C, non-HDL-C, FSH, LH levels were significantly higher than the control group, while HDL-C, E2 lower than the control group, perimenopausal group E2 and TC, TG, LDL-C, non-HDL-C, FSH and LH, and positively correlated with HDLC. HDL-C increased with the increase of E2 level. Level decreased and increased; non-HDL-C and TG, LDL-C showed a linear relationship. Conclusions E2 levels in perimenopausal women are lower than those in normal women, and their changes are related to non-HDL-C. Non-HDL-C may serve as a new target for lipid-lowering management.