由视神经炎(Optic Neuritis下简称ON)发展为多发性硬化(Multiple Sclerosis下简称MS)占相当数量的病人,基于随访的方法及时间长短不一,曾报告发生率为13～87%.关于ON作为MS的一个首发征象,西方国家报告约占25%病例,而日本所见的病例占43%.有报告以ON起病的MS是预后好的一个征象,多见于良性病例.本研究系收集多中心情报系统诊断标准统一的1271例MS进行分析.女754,男517.平均发病年龄 The number of patients with Multiple Sclerosis (MS) who develop from Optic Neuritis (ON for short) has been reported to range from 13% to 87% based on follow-up and length of time. As a first sign of MS, Western countries reported about 25% of cases, compared with 43% of those seen in Japan.It has been reported that onset of ON with MS is a good prognosis and is more common in benign cases. Multiple central intelligence system diagnostic criteria for a unified 1271 MS were analyzed.Female 754, male 517. The average age of onset