目的：探讨载脂蛋白Ｅ（ＡｐｏＥ）基因多态性与急性心肌梗死及血胆固醇水平的关系。方法：５０例急性心梗患者及１００例正常人，采用聚合酶链反应—限制性片段长度分析ＡｐｏＥ的基因型，并按标准酶法及免疫学方法测定血脂和载脂蛋白。结果：Ｅ４等位基因及基因型频率在病例中均明显高于对照组（Ｐ＜００５），而在病例组中共带Ｅ４患者血胆固醇也高于Ｅ３３患者（Ｐ＜００５）。结论：本研究表明ＡｐｏＥ基因多态性与急性心梗相关，并影响血胆固醇水平 Objective: To investigate the relationship between apolipoprotein E (ApoE) gene polymorphism and acute myocardial infarction and blood cholesterol levels. Methods: Fifty patients with acute myocardial infarction and 100 healthy controls were enrolled in this study. The genotypes of ApoE were determined by polymerase chain reaction - restriction fragment length analysis. Lipoproteins and apolipoproteins were determined by standard enzymatic and immunological methods. Results: The frequencies of E4 allele and genotype were significantly higher in cases than those in control group (P <005), while those with E4 in patients with E4 were also higher than those in E33 (P <005) ). Conclusion: This study shows that ApoE gene polymorphism is associated with acute myocardial infarction and affects blood cholesterol levels