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目的：探讨高压氧（ＨＢＯ）对大鼠急性局灶性脑缺血再灌注损伤血管通透性的影响。方法：应用血管内细丝栓堵脑中动脉（ＭＣＡ）的局灶性脑缺血大鼠模型。利用免疫组织化学方法，观察ＭＣＡ缺血１小时，再灌注４、１１、２３、７１小时脑血管通透性的变化，在以上期间同时应用常压纯氧和常规临床治疗压力０．２５ＭＰａＨＢＯ于开始缺血后２、９、２１、４５和６９小时分别治疗１次（１小时）。结果：常压纯氧组与缺血再灌注（ＩＲ）组相比脑水肿面积无明显差异，而ＨＢＯ组和ＩＲ组相比脑水肿面积分别缩小了１２．２８％（视交叉前平面），２０．４７％（视交叉平面）和８．５１％（视交叉后平面），两组间存在非常显著性差异（Ｐ＜０．０１）。结论：ＨＢＯ可明显抑制大鼠急性局灶性脑缺血再灌注损伤血管通透性的增加。
Objective: To investigate the effects of hyperbaric oxygen (HBO) on vascular permeability after acute focal cerebral ischemia-reperfusion injury in rats. Methods: Focal cerebral ischemia model was established by intravascular plug plugging middle cerebral artery (MCA). Immunohistochemical method was used to observe the change of cerebral vascular permeability at 1 hour, 4, 11, 23, and 71 hours after MCA ischemia. At the same time, both normal pressure oxygen and routine clinical treatment pressure 0.25 MPa HBO 2, 9, 21, 45 and 69 hours after ischemia were treated 1 (1 hour). Results: There was no significant difference in brain edema area between normal pressure oxygen group and ischemia reperfusion (IR) group, while the area of brain edema in HBO group and IR group decreased by 12.28% (anterior optic plane) 20.47% for the optic chiasm and 8.51% for the optic chiasm. There was a significant difference between the two groups (P <0.01). Conclusion: HBO can significantly inhibit the increase of vascular permeability in acute focal cerebral ischemia-reperfusion injury in rats.