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将48例急性心肌梗塞（AMI）患者随机分为阿司匹林每日疗法组（300mg，每日一次），小剂量疗法组（75mg，每日一次）、间歇疗法组（300mg，第三日一次）及未服阿司匹林组，观察患者血浆6-酮前列腺素F1α（6－keto－PGF1α）和血栓素B2（TXB2）浓度的变化。结果表明三种疗法抑制血小板血栓素A2（TXA2）的程度相似，小剂量疗法及间歇疗法对前列环素（PGI2）生成无累积性抑制．提示小剂量疗法和间歇疗法能改善PGI2－TXA2平衡，优于每日疗法组。
48 patients with acute myocardial infarction (AMI) were randomly divided into aspirin daily therapy group (300mg once daily), low-dose therapy group (75mg once daily), intermittent therapy group (300mg once on the third day) and In the aspirin group, the changes of plasma concentrations of 6-keto-PGF1α and TXB2 were observed. The results showed that the three therapies were similar in their inhibition of TXA2, and that low-dose and intermittent therapies produced no cumulative inhibition of prostacyclin (PGI2) production. Tip Low-dose therapy and intermittent therapy can improve PGI2-TXA2 balance, better than the daily therapy group.