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本文综述近十年来中草药中甙类化学成分合成研究的丰富成果。酚甙类化学成分的合成天麻甙(Gastrodin(1)又称对羟甲基苯-β-D-葡萄吡喃糖甙(P-Hy-dfoxymethylphenyl-p-D-glucopyra-noside)是天麻中分离得到的有效成分之一。临床上现已用于治疗神经衰弱及血管性头痛等。天然界天麻生成需要一种假蜜环菌,凶此药源受到限制。周俊等曾报道应用溴代2’,8’,4’,6’一四乙酰α-D-吡喃葡萄糖和对羟基苯甲醛缩合,然后经硼氢化钾还原,去乙酰化制得天麻甙(1)产率90％,同时还合成了天麻甙的类似物2-甲氧基-4-羟甲苯基-β-D-毗喃葡萄糖甙(2),2-甲氧基-4-甲酰苯基-β-D-吡喃葡萄糖
This article reviews the rich achievements in the study of chemical composition of terpenoids in Chinese herbal medicine in the past decade. Synthesis of Phenolphthalein Chemicals Gastrodin (1), also known as P-Hydoxymethylphenyl-pD-glucopyra-noside, is isolated from Gastrodia elata One of the active ingredients has been clinically used to treat neurasthenia and vascular headaches, etc. Naturally occurring gastrodia elata requires a type of honeysuckle fungus, and the source of the drug is limited. Zhou Jun et al. have reported the use of bromo 2’, Condensation of 8’,4’,6’-tetraacetyl-α-D-glucopyranose and p-hydroxybenzaldehyde, followed by reduction with potassium borohydride, deacetylation to obtain a 90% yield of gastrodin (1), and synthesis Gastrodin analogues 2-Methoxy-4-hydroxytolyl-β-D-glucopyranoside (2), 2-methoxy-4-formylphenyl-β-D-glucopyranose