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对96例陈旧性心肌梗塞心功能Ⅲ～Ⅳ级的病人随机分为压宁定组(A组,48例)和对照组(B组,48例)。两组均接受心力衰竭的常规治疗,A组在此基础上加用压宁定每晚15mg口服。结果显示,两组病人入选时的一般临床情况、心功能分级、彩色超声心动图测定的左室大小及左室射血分数均无显著性差异。治疗6个月后,两组NYHA心功能级别均明显降低,左室射血分数(LVEF 明显增加,左室收缩末内径(LVESV)及舒张末内径(LVEDV)缩小,A组LVESV和LVEDV缩小和LVEF的增加较B组更明显,但治疗后两组NYHA心功能分级的差异无显著性。提示小剂量压宁定口服可改善陈旧性心肌梗塞合并充血性心力衰竭病人的左心功能。
Ninety-six elderly patients with myocardial infarction with grade Ⅲ ~ Ⅳ cardiac function were randomly divided into naringin group (group A, 48 cases) and control group (group B, n = 48). Both groups received conventional treatment of heart failure, and on the basis of this, Group A was given oral pressure of 15 mg per night. The results showed that there was no significant difference in the general clinical situation, cardiac function classification, left ventricular ejection fraction and left ventricular ejection fraction measured by color echocardiography between the two groups. Six months after treatment, the NYHA functional levels were significantly decreased in both groups, LV ejection fraction (LVEF, left ventricular end-systolic diameter (LVESV) and end-diastolic diameter (LVEDV) The increase of LVEF was more obvious than that of group B, but there was no significant difference in NYHA function classification between the two groups after treatment, suggesting that low-dose nifedipine can improve left ventricular function in patients with old myocardial infarction and congestive heart failure.