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用ＩＣＰ－ＡＥＳ方法，对３０例大肠癌、２６例溃疡性结肠炎进行血清钼、锌、铬、铁、铜、锰、铅、铝、硒、铋、钡、钛、钴、钒等微量元素测定，并与２０例健康者对照。结果显示大肠癌组血清钼（±ＳＤ＝０．２１±０．１０μｍｏｌ／Ｌ）、锌（±ＳＤ＝１．６５±１．３４μｍｏｌ／Ｌ）、铬（±ＳＤ＝１．６５±１．３４μｍｏｌ／Ｌ）低于对照组钼（±ＳＤ＝１．１９±０．３１μｍｏｌ／Ｌ）、锌（±ＳＤ＝２０．９４±６．３１μｍｏｌ／Ｌ）、铬（±ＳＤ＝２．８８±１．１５μｍｏｌ／Ｌ），Ｐ分别＜０．０１、＜０．０５、＜０．０５；溃疡性结肠炎组钼（±ＳＤ＝０．２１±０．０８μｍｏｌ／Ｌ）低于对照组，Ｐ＜０．０５。提示微量元素代谢异常可能直接影响酶系统，使自由基失控，体内促氧化和抗氧化平衡失调，促使肿瘤的发生。钼、锌、铬在大肠癌的发病中起一定作用。
ICP-AES was used to detect trace elements such as molybdenum, zinc, chromium, iron, copper, manganese, lead, aluminum, selenium, tellurium, antimony, titanium, cobalt, and vanadium in 30 cases of colorectal cancer and 26 cases of ulcerative colitis. Determined and compared with 20 healthy subjects. The results showed that serum molybdenum (±SD=0.21±0.10μmol/L), zinc (±SD=1.65±1.34μmol/L), and chromium (±SD=1.65±1.34μmol) in colorectal cancer group /L) is lower than the control group molybdenum (±SD=1.19±0.31μmol/L), zinc (±SD=20.94±6.31μmol/L), chromium (±SD=2.88±1. 15μmol/L), P<0.01, <0.05, <0.05 respectively; molybdenum in the ulcerative colitis group (±SD=0.21±0.08μmol/L) was lower than the control group, P<0. .05. It is suggested that the abnormal metabolism of trace elements may directly affect the enzyme system, causing the free radicals to be out of control, the imbalance of prooxidant and antioxidation in vivo, and the occurrence of tumors. Molybdenum, zinc, and chromium play a role in the pathogenesis of colorectal cancer.