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核因子-kB(Nuclear factor,NF-kB)是一类能与许多种基因启动子部位的kB位点发生特异结合,并促进转录的蛋白质总称。在许多参与炎症和免疫反应的细胞因子、黏附分子基因的启动部位含有kB位点,而且体内外实验显示,NF-kB活化与上述因子的过度表达有关。心肌缺血再灌注损伤是一个包括中性粒细胞活化,多种因子及黏附分子过度表达,伴有多种炎性介质及信号传导分子参加的复杂操作过程。由于NF-kB调控多种炎性因子基因表达,推测其在心肌缺血再灌注损伤中起重要作用。
Nuclear factor-kappaB (NF-kB) is a general term for proteins that specifically bind to the kB locus of many promoter regions and promote transcription. In many cytokines involved in inflammation and immune responses, the promoter region of adhesion molecule contains kB sites, and in vitro and in vivo experiments show that NF-kB activation is associated with over-expression of these factors. Myocardial ischemia-reperfusion injury is a complex procedure that involves the activation of neutrophils, the overactivation of multiple factors and adhesion molecules, and the involvement of multiple inflammatory mediators and signaling molecules. As NF-kB regulates the expression of many inflammatory cytokines, it is speculated that it plays an important role in myocardial ischemia-reperfusion injury.