原发性中心性下颌骨癌是临床上比较少见的恶性肿瘤,由于肿瘤原发于下颌骨,使骨质溶解破坏,并可侵犯牙周膜引起牙齿松动、移位、疼痛、甚至脱落,此时常常继发感染而造成颌骨炎症,故临床往往长期误诊为慢性下颌骨骨髓炎而延误治疗,现报告三例如下:例1,女,48岁(住院号220019),患者四个月前左侧下颌磨牙疼痛、下唇麻木、左面部肿胀,曾切开引流及拔除(?),术后口内外创口反复流脓不止。疑为“下颌骨骨髓炎”从口外进路行刮治术,术后伤口仍不愈合。口内外肉芽组织前四次活检均为“慢性炎症”,第五次为“分化高的鳞状上皮癌”。即行颌颈联合根治术,术中见左半侧下颌骨 Primary central mandibular cancer is a relatively rare clinical malignant tumor, because the tumor in the mandible, the destruction of osteolysis, and can invade the periodontal ligament caused by tooth loss, displacement, pain, or even fall off, this Often secondary to infection caused by inflammation of the jaw, it is often long-term misdiagnosed as chronic mandibular osteomyelitis and delayed treatment, are reported as follows three cases: Case 1, female, 48 years old (hospital number 220019), four months ago Left mandibular molars pain, lower lip numbness, left facial swelling, had incision and drainage and removal (?), Repeated pus after mouth opening more than surgery. Suspected as “mandibular osteomyelitis” from the mouth line scraping surgery, the wound is still not healed. The first four biopsies of oral and external granulation tissue were all “chronic inflammation” and the fifth was “differentiated squamous cell carcinoma.” The line of jaw combined radical mastectomy, surgery, see the left half of the mandible