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目的 观察异丙酚对急性心肌梗死大鼠血液动力学影响的量-效关系以及心肌梗死范围和心肌超微结构的变化。方法 将急性心肌梗死模型的大鼠随机分为5组（n=8）,对照组（Ⅰ）,其余大鼠分别持续静脉输注30（Ⅱ）、45（Ⅲ）、60（Ⅳ）、75（Ⅴ）mg·kg-1·h-1异丙酚30min。测定输注异丙酚30min血药浓度,观察血液动力学、心肌梗死范围和心肌超微结构的变化。结果 血药浓度为（3.4±0.9）～（12.9±2.4）μg/ml时,平均动脉压（MAP）、心率（HR）、左室收缩压（LVSP）、左室内压力变化最大速率（±dp/dtmax）、心肌耗氧指数（MOCI）均呈剂量依赖性下降（P<0.05）,左心室舒张末压（LVEDP）无明显变化（P>0.05）,心肌梗死面积为23.7％～29.2％（P>0.05）,心肌超微结构无显著性差异。结论 在血药浓度（3.4±0.9）～（12.9±2.4）μg/ml范围内,异丙酚对血液动力学及心收缩功能呈剂量依赖性抑制,对心肌梗死范围和心肌细胞超微结构无明显影响。
Objective To observe the dose-response relationship between propofol and hemodynamics in acute myocardial infarction (AMI) rats and the changes of myocardial infarct size and myocardial ultrastructure. Methods The rats of acute myocardial infarction model were randomly divided into 5 groups (n = 8) and control group (Ⅰ). The other rats were given intravenous infusion of 30 (Ⅱ), 45 (Ⅲ), 60 (Ⅴ) mg · kg-1 · h-1 propofol for 30 min. The plasma concentration of propofol was measured 30min after infusion, and the changes of hemodynamics, myocardial infarction area and myocardial ultrastructure were observed. Results The mean arterial blood pressure (MAP), heart rate (HR), left ventricular systolic pressure (LVSP) and maximal rate of left ventricular pressure (± dp) were significantly different at the plasma concentrations from 3.4 ± 0.9 to 12.9 ± 2.4 μg / (P <0.05), left ventricular end-diastolic pressure (LVEDP) had no significant change (P> 0.05), myocardial infarct size ranged from 23.7% to 29.2% (P < P> 0.05), no significant difference in myocardial ultrastructure. Conclusions Propofol inhibits hemodynamics and cardiac contractility in a dose-dependent manner in the range of 3.4 ± 0.9 ~ (12.9 ± 2.4) μg / ml. The myocardial infarct size and the ultrastructure of myocardial cells Clearly affected.