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Progress in development of a simple, effective reversible male contraceptive hasbeen difficult due to the indispensable role of testosterone in spermatogenesis andmaintenance of secondary sexual characters. Efforts are in progress to develop methods,which do not interfere with testosterone production. These include blockade of FSHaction by immunization against FSH or FSHR, and interfere with sperm maturation byinterfering with estrogen action or by immunization against epididymal or sperm specificproteins. An evaluation of these various approaches for practical application is alsopresented.
Progress in development of a simple, effective reversible male contraceptive hasbeen difficult due to the indispensable role of testosterone in spermatogenesis and maintenance of secondary sexual characters. Efforts are in progress to develop methods, which do not interfere with testosterone production. These include blockade of FSHaction by immunization against FSH or FSHR, and interfere with sperm maturation by interfering with estrogen action or by immunization against epididymal or sperm specific proteins. An evaluation of these various approaches for practical application is alsopresented.