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宫内节育器的自然脱落是妇女中断使用的原因之一。易发生在改变子宫肌活动度的月经周期的后期。在大鼠观察,此种器内放置孕激素,其脱落率明显地减少,与前列腺素(PG)水平改变有关的孕激率的抗炎作用,可能是子宫肌肉活动度改变的基础。非甾体的抗炎药如indomethacin是环氧酶(Cyclooxygenase)活性的有效抑制剂,因此抑制PG及thromboxanes的产生,早先在大鼠的研究已显示indomethacin自硅橡胶器释放至宫腔,
One of the reasons women discontinue use is the natural shedding of an IUD. Easily occur in the late period of the menstrual cycle to change the activity of uterine muscle. In rats, progesterone in this device significantly reduced the rate of exfoliation, and prostaglandin (PG) level changes related to the pro-inflammatory rate of anti-inflammatory effect may be the basis of changes in uterine muscle activity. Non-steroidal anti-inflammatory drugs such as indomethacin are potent inhibitors of the activity of cyclooxygenase and therefore inhibit the production of PG and thromboxanes. Previous studies in rats have shown that indomethacin is released from the silicone rubber into the uterine cavity,