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[目的]分析大连市区1991～2010年5～19岁学龄期青少年恶性肿瘤流行趋势。[方法]利用5～19岁学龄期青少年恶性肿瘤新发病例资料,计算粗发病率、世界人口调整发病率(世调率)、年度变化百分比(APC),进行年龄、时期、队列三因素相互调整后的相对危险度和95%可信区间的估计,综合分析肺癌的年龄—时期—队列三因素变化趋势。[结果](1)发病概况:男性粗发病率和世调率分别为11.79/10万和11.80/10万,女性分别为11.99/10万和11.89/10万。白血病、脑瘤和恶性淋巴瘤位居学龄期青少年人群恶性肿瘤的前3位,构成比分别为34.14%、17.71%和9.92%。(2)时间趋势分析:男性粗发病率和世调率的APC分别为0.50%(P>0.05)和-0.20%(P>0.05),女性为1.61%(P>0.05)和1.51%(P>0.05)。(3)流行趋势分析:男性发病年龄在10～岁组、1984～与1989～出生队列发病风险增加(P<0.05),女性在2006～2010时期、1979～与1984～出生队列发病风险增加(P<0.05)。[结论]白血病是威胁大连市区学龄期青少年健康的首位恶性肿瘤,男性脑瘤和女性甲状腺癌发病的上升趋势值得关注。
[Objective] To analyze the prevalence of teenagers malignant tumors of school age from 5 to 19 in 1991 ~ 2010 in Dalian. [Methods] The data of incidence of malignant neoplasms in school-aged adolescents aged 5 ~ 19 years were used to calculate the incidence of gross morbidity, the incidence of world population adjustment (APF), annual change percentage (APC), age, Adjusted relative risk and 95% confidence interval estimates, a comprehensive analysis of lung cancer age-period-cohort three-factor trend. [Results] (1) Morbidity profile: The prevalence rates of males and females were 11.79 / lakh and 11.80 / lakh, respectively, and the females were 11.99 / lakh and 11.89 / lakh respectively. Leukemia, brain tumor and malignant lymphoma rank among the top 3 malignant tumors in school-aged adolescents with the proportions of 34.14%, 17.71% and 9.92%, respectively. (2) Time trend analysis: The APC rates of males were 0.50% (P> 0.05) and -0.20% (P> 0.05), 1.61% (P> 0.05) and 1.51% > 0.05). (3) Trend analysis: The incidence of male cohort increased from 10 years old to 1984 ~ 1989 birth cohorts (P <0.05). The incidence of female cohort increased from 2006 to 2010, from 1979 to 1984 P <0.05). [Conclusion] Leukemia is the first malignant tumor threatening the health of adolescents in school age in Dalian. The rising trend of the incidence of thyroid cancer and brain cancer in men is worth attention.