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过渡金属催化氰基化反应是合成芳基腈化物的重要手段之一。2004年,无毒、廉价的K4[Fe(CN)6]首次被用来代替传统的KCN、NaCN及CuCN等作为氰源用于芳基卤代物的氰基化反应。K4[Fe(CN)6]作为氰源时无需复杂的预处理,其6个氰根均可参与反应。本文主要综述了近年来K4[Fe(CN)6]作为氰源用于卤代芳烃和芳基氟代磺酸酯的氰基化反应,介绍了在钯催化剂和铜催化剂作用下,以K4[Fe(CN)6]为氰源的氰基化反应在配体、反应介质和底物适用范围等方面的研究成果。
Transition metal catalytic cyanation reaction is one of the important means of synthesizing aryl nitrile compounds. In 2004, non-toxic and inexpensive K4 [Fe (CN) 6] was firstly used to replace the traditional cyanogen reactions of KCN, NaCN and CuCN as cyanogens for aryl halides. K4 [Fe (CN) 6] as a cyanide source without complex pretreatment, the six cyanide can participate in the reaction. This review summarizes the cyanation reaction of K4 [Fe (CN) 6] as a cyanide source for halogenated aromatic hydrocarbons and aryl fluorosulfonates in recent years. The effects of palladium catalyst and copper catalyst on the K4 [ Fe (CN) 6] is a research result on the cyanide reaction of cyanide in the application range of ligand, reaction medium and substrate.