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肝病是造成自发性或术后口腔出血的主要原因之一。肝病病人如肝硬化或严重肝炎常表现为依赖维生素K的凝血因子(即凝血酶原、凝血因子Ⅶ、Ⅸ和Ⅹ)在血浆中水平低下;血小板减少;纤维蛋白溶解活性增加;纤维蛋白聚合障碍。硬化肝脏中含有见于组织修复过程中的纤维蛋白溶解酶活化质,纤维蛋白溶解酶的血浆抑制因子的稳定性似较正常为低。作者报告了4例有不同程度肝细胞损害并发口腔出血病人被治疗的新疗法。这些病人分别患有肝硬化或慢性活动性肝炎,因牙龈持续出血或拔牙而就诊。血液系统检查3例有贫血,4例血小板均低,所有病人都有不同
Liver disease is one of the main causes of spontaneous or postoperative oral bleeding. Patients with liver disease, such as cirrhosis or severe hepatitis, are often characterized by low plasma levels of thrombin (ie, prothrombin, coagulation factors Ⅶ, Ⅸ and Ⅹ), thrombocytopenia, increased fibrinolytic activity, fibrinolytic disorders . The hardened liver contains fibrinolytic activators found during tissue repair, and the plasma inhibitor of fibrinolytic enzymes appears to be less stable than normal. The authors report four new treatments that treat patients with different degrees of hepatocellular damage and oral bleeding. These patients had cirrhosis or chronic active hepatitis, respectively, due to continuous bleeding gums or tooth extraction and treatment. 3 cases of anemia blood test, 4 cases of platelets are low, all patients have different