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为观察幽门胆汁反流对胃窦粘膜损伤、有关症状及幽门螺杆菌(Helicobacterpylori,HP)感染的影响,采用测空腹胃液胆汁酸浓度130例,按其含量高低分为轻、中、重3种程度的幽门胆汁反流组。结果显示,各组胃窦粘膜损伤及临床症状与幽门胆汁反流程度无明显关系(P均>0.05),但发现幽门胆汁轻度反流组的胃窦腺体萎缩发生率明显低于中、重度组(P均<0.05),幽门胆汁中度反流组HP感染率明显高于轻、重度幽门胆汁反流组(P均<0.05)。提示幽门反流液中的胆汁酸对胃粘膜损伤不是首要因素,慢性胃炎是受多种致病因素的影响。必须有效抑制幽门胆汁反流才能减少HP的感染及延缓萎缩性胃炎的发生发展。
To observe the effects of pylorus bile reflux on the gastric mucosa injury, the symptoms and the infection of Helicobacterpylori (HP), 130 cases of fasting gastric juice bile acid concentration were divided into light, medium and heavy according to their content Degree of pylorus bile reflux group. The results showed that gastric mucosal injury and clinical symptoms in each group had no significant relationship with the degree of pyloric reflux (P> 0.05). However, the incidence of antral glandular atrophy in mild reflux group was significantly lower than that in pylorus, (P <0.05). The HP infection rate in pyloric biliary moderate reflux group was significantly higher than that in mild and severe pyloric reflux group (all P <0.05). Tip pylorus reflux fluid in the bile acid damage to the gastric mucosa is not the primary factor, chronic gastritis is affected by a variety of risk factors. Must effectively inhibit pyloric reflux in order to reduce the HP infection and delay the occurrence of atrophic gastritis.