目的为探讨新生儿缺血缺氧性脑病与血清酶谱及血液黏滞度的关系,以及血液黏滞度与器官损害的关系。方法选择2008-04-2010-09在秦皇岛市妇幼保健院新生儿科住院的100例新生儿缺血缺氧性脑病患儿做了心肌酶谱、心电图及血液流变学(简称血流变)检测,按脑病的严重程度分成两组:轻度组、重度组。并观察轻度组及重度组治疗前、后血清酶谱变化与血液黏滞度的关系,以及脑病患儿有无器官损害者血液黏滞度的比较。结果新生儿缺血缺氧性脑病患儿血清酶谱均有不同程度的升高,轻度组及重度组治疗前、后血清酶谱与血液黏滞度的变化,经t检验差异有统计学意义(P<0.01),全部病例血液黏滞度均升高,合并心、脑等器官损害病例的血液黏滞度较未发生损害的病例明显升高,说明器官损害与血液高黏滞度有密切关系。结论提醒临床医生提高对脑病合并器官损害的认识,对患儿早期进行二项监测,并对新生儿缺血缺氧性脑病早期采取干预措施,积极治疗,对提高生存质量有重大意义。 Objective To explore the relationship between neonatal hypoxic-ischemic encephalopathy and serum zymogram and blood viscosity, as well as the relationship between blood viscosity and organ damage. Methods 2008-04-2010-09 Myocardial zymogram, electrocardiogram and hemorheology (referred to as blood rheology) in 100 neonates with hypoxic-ischemic encephalopathy hospitalized in Department of Neonatology, Maternal and Child Health Hospital of Qinhuangdao City, , According to the severity of encephalopathy divided into two groups: mild group, severe group. The changes of serum zymogram and blood viscosity before and after treatment were observed in mild and severe groups, and the blood viscosity of those with or without organ damage were compared. Results Serum zymogram of neonates with hypoxic-ischemic encephalopathy increased in varying degrees. The changes of serum zymogram and blood viscosity before and after treatment in mild and severe groups were statistically significant (P <0.01). The blood viscosity of all cases increased. The blood viscosity of organ damage cases such as heart and brain were significantly higher than those without injury, which indicated that organ damage and high blood viscosity had close relationship. Conclusion It is of great significance for clinicians to remind clinicians to raise their awareness of organ damage in patients with encephalopathy. To monitor their children early and to take early intervention and active treatment of neonatal hypoxic-ischemic encephalopathy is of great significance to improve the quality of life.