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目的观察黄芪注射液雾化吸入治疗对反复呼吸道感染(RRTI)患儿细胞免疫功能的影响。方法将55例RRTI患儿分为A组30例和B组25例,另设C组正常对照组20例。A组在常规治疗基础上加用黄芪注射液雾化吸入治疗,2次/d,连用10 d为1个疗程。采用流式细胞仪观察A、B组于治疗前后、C组于健康体检时外周血T细胞亚群(CD3、CD4、CD4/CD8)量的变化。结果 A组黄芪治疗前与C组正常对照组比较,CD3、CD4、CD4/CD8均明显低于对照组(P<0.01),A组黄芪治疗前及治疗后比较,CD3、CD4、CD4/CD8均明显回升(P<0.01),而A、B组治疗后比较差异有统计学意义。结论黄芪注射液雾化吸入给药可提高RRTI患儿细胞免疫功能,且操作简单方便,疗效显著,不良反应小,迅速发挥治疗作用。
Objective To observe the effect of astragalus injection aerosol inhalation on cellular immune function in children with recurrent respiratory tract infection (RRTI). Methods 55 cases of RRTI were divided into A group of 30 cases and B group of 25 cases, another C group of normal control group of 20 cases. A group in the conventional treatment plus astragalus injection inhalation therapy, 2 times / d, once every 10 d for a course of treatment. The changes of T cell subsets (CD3, CD4, CD4 / CD8) in peripheral blood of healthy group A and B before and after treatment were observed by flow cytometry. Results Before treatment, the CD3, CD4 and CD4 / CD8 of astragalus in group A were significantly lower than those in control group before treatment (P <0.01) Were significantly increased (P <0.01), while the A and B groups after treatment, the difference was statistically significant. Conclusion Astragalus injection aerosol inhalation can improve cellular immune function in children with RRTI, and the operation is simple and convenient, the effect is significant, the adverse reaction is small, quickly play a therapeutic role.