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colony stimulating factor(克隆刺激因子,CSF)是造血细胞在体外培养形成粒细胞-巨噬细胞系克隆过程中,起促进作用的体液因子。根据作用于造血干细胞的不同分化程度,CSF可分为多能祖细胞克隆刺激因子(multi-CSF,interleukin-3)、粒-巨噬祖细胞克隆刺激因子(granulocyte-macrophage-CSF,GM-CSF)、粒祖细胞克隆刺激因子(granulocyte-CSF,G-CSF)、巨噬祖细胞克隆刺激因子(macrophage-CSF,M-CSF,CSF-1)及存在于人尿中的CSF hu(hu∶human urine)等几种。现重点介绍临床已经应用及准备应用的几种CSF。
Colony stimulating factor (CSF) is a humoral factor that promotes the development of hematopoietic cells during in vitro culture of granulocyte-macrophage lineage clones. According to the different degrees of differentiation on hematopoietic stem cells, CSF can be divided into multi-CSF (interleukin-3), granulocyte-macrophage-CSF ), Granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF, CSF-1) and CSF hu human urine) and several other. Now highlight the clinical applications have been prepared and the application of several CSF.