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本文报道2例T前淋巴细胞白血病(T-PLL)变异型。在光学显微镜下,该2例的特征为:细胞中等大小(较前淋巴细胞小),胞浆相对丰富,嗜硷性。核形通常规则,多数细胞有一个小核仁。在电镜下,瘤细胞似比T-PLL成熟,核切迹较少,异染色质较浓集。核仁常可见到,但比典型前淋巴细胞为小,亦较不明显。细胞器、线粒体和高尔基体在胞浆中较少。白细胞计数2例均中度升高(分别为49与59×10~9/L),但比T-PLL低。例1脾在左肋下4cm,酸性磷酸酶(AP)及α-萘酚乙酸酯酶(ANAE)2例均阳性,但反应较T-PLL为弱。表面标记检查结果,例1为OKT1+,OKT3+,OKT4+,OKT8-表型;例2为OKT1+,OKT3+,OKT4+,OKT8+膜表达。例2的抗Tac单抗阳性(但HTLVI阴性),显示辅助T细胞活性正常,PHA反应正常,而天然
This article reports two cases of T-lymphoblastic leukemia (T-PLL) variant. Under optical microscope, the characteristics of the two cases were: medium size (smaller than the former lymphocytes), relatively abundant cytoplasm, alkalophilicity. The nucleus is usually the rule that most cells have a small nucleolus. Under electron microscopy, tumor cells appear to be more mature than T-PLL with fewer nuclear excitations and more heterochromatin. Nucleolus can often be seen, but smaller than the typical pre-lymphocytes, also less obvious. Organelles, mitochondria and Golgi in the cytoplasm less. Two cases of leukocyte count were moderately elevated (49 and 59 × 10 ~ 9 / L respectively), but lower than T-PLL. Example 1 spleen in the left rib 4cm, acid phosphatase (AP) and α-naphthol acetate enzyme (ANAE) 2 cases were positive, but the reaction was weaker than the T-PLL. The results of surface marker test were as follows: OKT1 +, OKT3 +, OKT4 +, OKT8-phenotype in Example 1; and OKT1 +, OKT3 +, OKT4 +, OKT8 + membrane in Example 2; The anti-Tac monoclonal antibody of Example 2 (but negative for HTLVI) showed normal helper T cell activity and normal PHA response, whereas natural