论文部分内容阅读
目的探讨血清胱抑素C(Cys C)在早期糖尿病肾病患者中水平变化及其诊断价值。方法选择126例糖尿病(DM)患者,其中单纯糖尿病组66例,早期糖尿病肾病(DN)组60例,并选择60例健康体检者作为对照。检测三组研究对象血清肌酐(Scr)、尿素氮(BUN)及Cys C水平并进行统计学分析。结果早期DN组中Cys C水平明显高于单纯DM组及健康对照组(P<0.01),但单纯DM组和早期DN组之间Scr、BUN、Ccr水平无明显差异(P>0.05);早期DN组中Cys C阳性检出率为58.33%,明显高于Scr(21.67%,P<0.01)和BUN(20.00%,P<0.01);早期DN组中Cys C与Scr、BUN均呈高度正相关(P<0.01)。结论血清Cys C是诊断早期糖尿病肾病的敏感指标。
Objective To investigate the level of serum cystatin C (Cys C) in patients with early diabetic nephropathy and its diagnostic value. Methods Sixty-six patients with diabetes mellitus (DM) were selected, including 66 cases of simple diabetic group and 60 cases of early diabetic nephropathy (DN) group. Sixty healthy subjects were selected as controls. The levels of serum creatinine (Scr), blood urea nitrogen (BUN) and Cys C in the three groups were detected and statistically analyzed. Results The level of Cys C in early DN group was significantly higher than that in DM group and healthy control group (P <0.01), but the levels of Scr, BUN and Ccr in simple DN group and early DN group had no significant difference (P> 0.05) The positive rate of Cys C in DN group was 58.33%, which was significantly higher than that of Scr (21.67%, P <0.01) and BUN (20.00%, P <0.01) Related (P <0.01). Conclusions Serum Cys C is a sensitive index for the diagnosis of early diabetic nephropathy.