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选择中度以上慢性肝炎和早期肝硬化患者120例，分为治疗组和对照组各60例。治疗组采用软肝冲剂治疗，对照组以干扰素治疗，疗程均为3个月，观察血清透明质酸（HA）、Ⅲ型前胶原肽（PⅢP）、Ⅳ型胶原（C-Ⅳ）、板层素（LN）等肝纤维化指标，以及肝功能和病毒复制指标。结果治疗组HA、C-Ⅳ、LN、ALT和γ-Glb明显下降，与对照组比较有显著性差异（P＜0．05），HBeAg和HBVDNA阴转率略低于对照组。结果表明软肝冲剂治疗肝纤维化作用比较全面，且在一定程度上优于干扰素。
120 patients with moderate or above chronic hepatitis and early cirrhosis were selected and divided into treatment group and control group with 60 cases each. The treatment group was treated with Ruangan granules and the control group was treated with interferon for 3 months. Serum hyaluronic acid (HA), type III procollagen (PIIIP), type IV collagen (C-IV), and plate were observed. Titerin (LN) and other indicators of liver fibrosis, as well as indicators of liver function and virus replication. Results The HA, C-IV, LN, ALT and γ-Glb levels in the treatment group were significantly decreased compared with the control group (P<0.05). The negative conversion rate of HBeAg and HBV DNA was slightly lower in the treatment group than in the control group. The results showed that the effect of Ruangan Granules in the treatment of hepatic fibrosis was relatively comprehensive and to a certain extent superior to interferon.