目的：探讨雷公藤红素对ＨＭＣ１细胞表达Ｆａｓ、ＦａｓＬ的影响及与凋亡的关系。方法：用流式细胞仪检测细胞凋亡和Ｆａｓ、ＦａｓＬ的表达。结果：ＨＭＣ１细胞能自发表达Ｆａｓ，不表达ＦａｓＬ。经雷公藤红素作用，Ｆａｓ呈先升后降的变化，ＦａｓＬ低水平表达。Ｆａｓ阳性率下降与凋亡率增加相关。结论：Ｆａｓ可能是雷公藤红素诱导ＨＭＣ１细胞凋亡的途径之一 Objective: To investigate the effect of Tripterine on the expression of Fas and Fas-L in HMC-1 cells and its relationship with apoptosis. Methods: Flow cytometry was used to detect the apoptosis and expression of Fas and Fas-L. Results: HMC 1 cells spontaneously express Fas, Fas-L does not express. Tripterine effect, Fas was increased first and then decreased, Fas  L expression at low levels. The decrease of Fas positive rate is related to the increase of apoptosis rate. Conclusion: Fas may be one of the pathways that tripterine induces HMC-1 cell apoptosis