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抑制素——一种性腺糖蛋白,可选择性抑制FSH而不影响垂体的LH释放。目前已从多种动物中分离得到。在妇女中抑制素由卵巢颗粒细胞产生并积累在滤泡液中。作者从排卵前的卵巢滤泡获得颗粒黄体细胞并且进行体外培养12天以观察它们的抑制素分泌能力。作者用高敏感度的羊垂体细胞生物测定,观察到基础抑制素产生的变化与时间有关,培养的最初4天分泌量最大(每2天为48±15单位/百万细胞),至12天时,分泌量下降5倍,而培养中有hLH存在时,4至6天后,抑制素的分泌与hLH的浓度成比例增加(hLH为10ng/ml时,其最大
Inhibin, a gonadal glycoprotein, selectively inhibits FSH without affecting pituitary LH release. Has been isolated from a variety of animals. In women, inhibin is produced by ovarian granulosa cells and accumulates in the follicular fluid. The authors obtained granular luteal cells from ovarian follicles before ovulation and cultured in vitro for 12 days to observe their statin secretion capacity. Using high-sensitivity goat pituitary bioassays, the authors observed changes in basal statin production associated with time, with the highest volume of secretions in the first 4 days of culture (48 ± 15 units / million cells every 2 days), up to 12 days , A 5-fold decrease in secretion, whereas in the presence of hLH in culture, after 4 to 6 days, the secretion of inhibin is increased in proportion to the concentration of hLH (at a maximum of 10 ng / ml hLH