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目的分析中性粒细胞表面CD64指数在胎膜早破新生儿感染早期诊断中的临床意义。方法选择2014年1~12月收治的胎膜早破新生儿80例,按出院诊断分为败血症组(18例)、局部感染组(28例)与非感染组(34例),比较3组脐血中性粒细胞表面CD64指数。结果非感染组CD64阳性率为8.82%(3/34)、局部感染组阳性率为60.71%(17/28),败血症组阳性率为94.44%(17/18),3组CD64阳性率比较差异有统计学意义(P<0.01)。3组脐血中性粒细胞表面CD64指数非感染组<局部感染组<败血症组,组间比较有统计学意义(P<0.01);3组WBC计数及CRP水平比较差异无统计学意义(P>0.05)。结论脐血中性粒细胞表面CD64指数会随着胎膜早破新生儿感染的严重程度的增加而升高,在胎膜早破新生儿感染早期预测中具有较高的价值。
Objective To analyze the clinical significance of neutrophil CD64 index in the early diagnosis of neonatal premature rupture of membranes. Methods Eighty newborn infants with premature rupture of membranes admitted from January to December 2014 were selected and divided into sepsis group (n = 18), local infection group (n = 28) and non-infected group (n = 34) Cord blood neutrophil surface CD64 index. Results The positive rate of CD64 in non-infected group was 8.82% (3/34), the positive rate in local infection group was 60.71% (17/28), and the positive rate in sepsis group was 94.44% (17/18) There was statistical significance (P <0.01). There was no significant difference in WBC count and CRP level between the three groups (P <0.01). There was no significant difference between the three groups in the non-infected CD64 index of neutrophil > 0.05). Conclusion The CD64 index on cord blood neutrophils increases with the severity of neonatal infection of premature rupture of membranes and is of high value in the early prediction of neonatal premature rupture of membranes.