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目的:观察西咪替丁联合双嘧达莫治疗小儿秋季腹泻的临床疗效。方法:选择2009年6月-2010年6月102例秋季腹泻患儿,随机分为2组。对照组51例采用常规治疗;观察组51例,在对照组基础上采用西咪替丁20mg·kg-·1d-1,双嘧达莫4mg·kg-·1d-1,分3次于饭后口服。2组均5d为1个疗程。观察比较2组的临床疗效,平均退热、止泻时间和总疗程。结果:观察组的总有效率明显高于对照组,2组比较差异有统计学意义(P<0.05)。观察组的平均退热时间、平均止泻时间和总疗程均明显短于对照组,2组比较差异有统计学意义(P<0.05)。2组在治疗过程中均未见明显不良反应。结论:西咪替丁联合双嘧达莫治疗小儿秋季腹泻,可明显提高临床疗效,有效缓解症状,缩短治疗时间,并且安全性较好。
Objective: To observe the clinical effect of cimetidine combined with dipyridamole in the treatment of infantile autumn diarrhea. Methods: A total of 102 children with diarrhea in autumn from June 2009 to June 2010 were randomly divided into two groups. Fifty-one patients in the control group were treated routinely. In the observation group, 51 patients were treated with cimetidine 20 mg · kg-1d-1 and dipyridamole 4 mg · kg- · 1 d-1 on the basis of the control group, After oral administration. 2 groups were 5d for a course of treatment. Observed and compared the clinical efficacy of two groups, the average antipyretic, antidiarrheal time and the total course of treatment. Results: The total effective rate of the observation group was significantly higher than that of the control group, the difference between the two groups was statistically significant (P <0.05). The average antipyretic time, average antidiarrheal time and total duration of treatment in the observation group were significantly shorter than those in the control group. The difference between the two groups was statistically significant (P <0.05). No significant adverse reactions were observed in the two groups during the course of treatment. Conclusion: Cimetidine combined with dipyridamole treatment of children with autumn diarrhea can significantly improve clinical efficacy, effectively relieve symptoms and shorten the treatment time, and the safety is better.