我院配制1%盐酸地卡因注射液,用于腰麻。过去,配制本品时,灭菌前将溶液的pH值调节至5.6(参照U.S.P.)。可是在灭菌后,保存时间不长(一般在10天以后),即逐渐降低原有的麻醉效力;有时为了达到预期的麻醉效果,往往要增大原用量的1/2～1倍。我们的试验表明,本品的稳定性受pH的影响,pH在3.5～4.5时,本品较为稳定,因此把pH值调整为 Our hospital preparation of 1% cocaine hydrochloride injection for spinal anesthesia. In the past, when formulating this product, the pH of the solution was adjusted to 5.6 prior to sterilization (see U.S.P.). However, after sterilization, preservation time is not long (usually 10 days later), that is, gradually reduce the original anesthetic efficacy; sometimes in order to achieve the desired effect of anesthesia, often to increase the original amount of 1/2 to 1 times. Our tests show that the stability of the product affected by the pH, pH 3.5 to 4.5, the product is more stable, so the pH adjusted to