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作者报告两例因使用二甲氧苯基青霉素(methicillin)造成骨髓抑制的患者。一例男、63岁、患慢性葡萄球菌性骨髓炎,使用鏈霉素、氯霉素、万古霉素、大剂量青霉素(每天4500万单位)无效,改用methicillin,每天6克分4次間歇性靜脉滴注給药,治疗工16天后,发現骨髓抑制现象,白細胞計数由治疗前的11900/立方毫米降至3700/立方毫米,停药3周后才恢复到治疗前的状态。以后患者改用每天口服2克5-甲基-3-苯基-4-异噁唑基青霉素(oxacillin),治疗26天,未发
The authors report two patients who developed myelosuppression with methicillin. One male, 63 years old with chronic staphylococcal osteomyelitis, was discontinued with streptomycin, chloramphenicol, vancomycin, and a high dose of penicillin (45 million units per day) and switched to methicillin at 6 g daily for 4 intermittent After 16 days of treatment, bone marrow suppression was found. The white blood cell count was reduced from 11900 / mm3 before treatment to 3700 / mm3. After 3 weeks of withdrawal, the state of pre-treatment was restored. After the patient switched to oral administration of 2 grams of 5-methyl-3-phenyl-4-isoxazolyl penicillin (oxacillin) daily for 26 days without hair