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32例冠心病(合并高血压病24例,心功能Ⅱ级26例,Ⅲ级6例),男20例,女2例,年龄63.8±12.8岁。超声心动图检查示均为左室舒张功能不全,其中7例同时存在左室收缩功能不全。经心得安30mg/d口服治疗2—4周;给药前后分别用二维多普勒超声心动图观察左室收缩及舒张功能变化。结果示:治疗后,心率减慢,肱动脉收缩压及舒张压降低;左室收缩功能呈轻度抑制;左室舒张功能明显改善,多普勒血流频谱指标:A峰降低,E峰升高、A/E比值小、AI/TVI降低、PFR、NPFR均升高(P<0.05～0.001)。结论对以“舒张衰竭”为主的冠心病,尤其合并高血压病者,可以安全地使用β-受体阻滞剂心得安进行治疗。
32 cases of coronary heart disease (hypertension in 24 cases, heart function Ⅱ grade 26 cases, Ⅲ grade 6 cases), 20 males and 2 females, aged 63.8 ± 12.8 years. Echocardiography showed left ventricular diastolic dysfunction, including seven cases of left ventricular systolic dysfunction. The propranolol 30mg / d orally for 2-4 weeks; before and after administration of two-dimensional Doppler echocardiography were observed left ventricular systolic and diastolic function changes. The results showed that: after treatment, heart rate decreased, brachial artery systolic pressure and diastolic blood pressure decreased; left ventricular systolic function was mildly suppressed; left ventricular diastolic function improved significantly, Doppler flow spectrum indicators: A peak decreased, E peak High, A / E ratio was small, AI / TVI decreased, PFR, NPFR were increased (P <0.05 ~ 0.001). Conclusions For CHD with predominant “diastolic failure”, especially those with hypertension, beta-blocker can safely be used for the treatment of CHD.