肺癌是常见的恶性肿瘤,其中80%以上的肺癌组织学类型为非小细胞肺癌(non-small cell lungcancer,NSCLC)。目前尽管诊断治疗水平不断提高,但由于术后复发、转移、浸润等因素使得肺癌患者预后仍然较差[1]。化疗被广泛应用于大多数晚期患者(临床分期为Ⅲ期和Ⅳ期),但研究发现化疗不能从实质上改变大多数肺癌的远期结局,并且化疗 Lung cancer is a common malignancy, of which over 80% of lung cancer histological types are non-small cell lung cancer (NSCLC). At present, despite the continuous improvement of diagnosis and treatment, but because of recurrence, metastasis, invasion and other factors make the prognosis of lung cancer patients is still poor [1]. Chemotherapy is widely used in most advanced patients (clinical stage III and IV), but studies have found that chemotherapy does not substantially alter the long-term outcomes of most lung cancers, and chemotherapy