COX-2是外周组织炎症反应的主要成分,在脑内COX-2的功能不同于外周组织,在正常生理状况下表达,参与脑的基本功能,有更严格的调控。中枢系统内的表达也与炎性前体物质的产生有关,与急慢性疾病所致的神经变性密切相关,但同时也表现抗炎的特性,作用表现双重性,本文对此进行了综述。 COX-2 is the main component of inflammatory reaction in peripheral tissues. The function of COX-2 in the brain is different from that of peripheral tissues. Under normal physiological conditions, COX-2 participates in the basic functions of the brain and has more strict regulation. The expression of the central nervous system is also related to the production of inflammatory precursors, and neurodegeneration caused by acute and chronic diseases are closely related, but also shows anti-inflammatory properties, the performance of duality, this article reviewed.