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氨茶碱是治疗支气管哮喘病的有效药物,但由于治疗范围狭窄(10～20μg/ml), 个体差异及毒副反应较大,临床应用受到一定限制。80年代以来,国内许多药学工作者进行了氨茶碱血药浓度监测和个体化给药的研究工作,为临床合理用药创造了有利条件.但测定血药浓度一般需多次自静脉取血,会给患者造成一定的损害和痛苦,不易为年老体弱和儿童患者接受。由于人们发现唾液中药物浓度通常与血清浓度相关,因此利用唾液作为样本,就成为一种简便的、无损害的、并能反应血药浓度的监测方法。
Aminophylline is an effective drug for the treatment of bronchial asthma, but due to the narrow treatment range (10 ~ 20μg / ml), individual differences and toxicity, the clinical application of certain restrictions. Since the 1980s, many domestic pharmaceutical workers carried out research on the monitoring of the concentration of aminophylline and individualized administration, which has created favorable conditions for clinical rational use of drugs, but the determination of plasma concentration usually takes multiple times from the venous blood, Will cause some damage and pain patients, not easy for frail elderly and children patients to accept. Since saliva has been found to be commonly associated with serum concentrations, saliva is a convenient, nondestructive, and monitoring method of plasma concentration.