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De Larco和Todaro最先分离出了灰鼠肉瘤病毒(MSV)转化细胞生长因子,并把它看作肿瘤表现型表达的自发信号。由于这些生长因子能与表皮生长因子(EGF)的受体相互作用,所以与EGF是部分同源的。然而,这两种多肽的抗原性是不同的。显然;由肉瘤提取的因子,只是几种多肽生长因子中的一种,它促进在各种转化细胞中出现转化表现型。这些转化生长因子(TGF)被认为是激素样的
De Larco and Todaro first isolated murine sarcoma virus (MSV) to convert cell growth factor and considered it as a spontaneous signal for tumor phenotype expression. Since these growth factors interact with receptors for epidermal growth factor (EGF), they are partially homologous to EGF. However, the antigenicity of these two polypeptides is different. Obviously, the factors extracted by sarcomas are just one of several polypeptide growth factors that promote the appearance of transformed phenotypes in a variety of transformed cells. These transforming growth factors (TGFs) are thought to be hormone-like